I agree that the "principle of sufficient reason" exists within Nature, but that is a redundant and convoluted notion that only allows itself to be used by those who wish to "prove" that Nature has a cause. If you have an isolated system such as the Universe/Nature, you have something that be could be described absolutely by an observer (i.e. determining the laws of nature), and thus every cause and effect within it. But such an observer could not then say that Nature also has a cause, given that they could not make such an observation.
I would say an axiom of science is that it must be based on observation, not supposition. You may disagree with that axiom, but it should be self-evident that if there is such a thing as knowledge about the phenomenal world, it must come from observation and not supposition.
Despite my view that causality exists in Nature, I am aware of the theory that the universe is holographic and that time is merely an illusion. Thus it may be better to say I find the idea of causality useful for describing Nature, even if it may not be correct (it may not be falsifiable either).