If you need drugs to fully understand a person, well, that's red flag number one. Drugs enhance things in the best of the interpretations of their use. You should still "get it" without em', but they just make "getting it" better. Like if you pair the right beer or wine with a matching meal or delicacy. Both are awesome on their own, but together they're even better!
If you need a drug to make something palatable, well, that can't be good. From both ends to be honest.