Sure it's different, fat nerds are ewwwww...
Would I hire a morbidly obese individual to be a Victoria secret model, no. There's a lot of everyday prejudice and everyday discrimination that occurs in the world, we give and we take in these areas of life because people aren't perfect. However there have been measures in the present and past which disenfranchise individuals or problems which arise from these everyday prejudices that result in harm. Things like poll taxes or laws to restrict voting rights in order to disenfranchise individuals in society, or the death penalty which is applied unequally for the same crime because of the color of someone's skin or based on ethnic background.
The world is not equal, fair or just, people are not the same. We can only hope to do what we can in the face of inequality, unfairness and injustice. We can only hope to give everyone a fair shake at opportunity, give some aid to those that have been wronged, and make what amends which can be made.